Odontogenic tumors are heterogeneous group of lesions with diverse histopathological and clinical features. Ameloblastic fibro-dentinoma. The ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor. .. It is also distinguishable from ameloblastic fibro-dentinoma not only because it. Peripheral ameloblastic fibro-dentinoma (AFD) is an extremely rare benign mixed odontogenic tumor. From a review of the English-language literature, to the.

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Ameloblastic fibro-odontoma

There was no evidence of mucosal ulceration. Embryonic and other stem cells have long telomeres, which become shorter during differentiation or aging but are stabilized again in tumorigenesis [ 25 ]. The second variant is a hamartomatous non-neoplastic lesion that appears to be able to differentiate into an ameloblastic fibroodontoma and mature further into a complex odontoma.

Localized reactive hyperplastic lesions in gingiva can be classified into 4 subcategories: Report on two new cases. The fibrous element varies from abundantly cellular to mature collagenous tissue, and primitive dental papilla-like appearance could not be found.

Ameloblastic fibro-odontoma

Reconstruction of the mandible was performed following resection [ Figure 6 ]. Ameloblwstic recurrence rate of intraosseous AFO is uncommon: None, Conflict of Interest: Kannan Venugopal was responsible for writing the article.

Case report A year-old girl was referred to oral and maxillofacial surgery department with an incidental radiological finding of radiopaque mass in the posterior region of maxilla. The IHC results showed that amelogenin was strongly expressed in enamel epithelium.

The patient is kept under regular follow-up. AFD is defined as a neoplasm similar to AF that concurrently shows formation of dentin or dentinoid [ 20 ame,oblastic. Ameloblastic fibrodentinoma and ameloblastic fibro-odontoma: CD31 staining appeared in the endothelial cells of the tumor stroma, especially in the area adjacent to the enamel epithelium. Ameloblastic fibro-odontoma AFO is an uncommon mixed odontogenic tumour. Ameloblastic fibrodentinoma involving anterior maxilla: Occlusal radiograph revealed expansion of buccal cortical plate with few radiopaque areas in a well-defined radiolucent lesion Click here to view.


In this WHO classification of odontogenic tumors, AFD is defined as a neoplasm similar to AF that also shows inductive changes leading to the formation of dentin.

A trapezoidal flap was elevated and a thin bone covering the surface of the lesion was removed Fig. J Oral Maxillofac Surg ; The cavity was irrigated carefully and the debris was removed.

Case Presentation A three-year-seven-month-old girl was referred to the Pediatric Dentistry Section, Department of Stomatology, National Cheng Kung University Hospital, to have a swelling and erythematous mass on the facial gingiva of the primary maxillary right central incisor evaluated.

Because peripheral AFO is so rare, there is no published study that estimates its recurrence rate after surgical excision. More female cases are reported than male ones. The buccal and lingual vestibule was obliterated and the expansion of debtinoma cortical plate was relatively higher.

An analysis of the interrelationship of the mixed odontogenic tumors — ameloblastic fibroma, ameloblastic fibroodontoma, dentnoma the odontomas. Many small blood vessels appeared in the connective tissue surrounding the odontogenic epithelium.

Ethical approval This case report is the surgical treatment of an odontogenic tumour in the maxilla. Here, we present one such a rare case of AFD occurring in a 5-year-old female patient.

Here, we report a case of aggressive AFD that presented as a rapidly growing mass associated with pain and presenting with resorption and perforation of the lingual cortical plate. Conservative excision of the tumor is the treatment of choice. How to cite this article: It is important to note that in the revised WHO classification of odontogenic tumors, AFD and dentinoma are used synonymously.

CD44, a hyaluronic acid receptor, is one of the most commonly studied surface amepoblastic, which is expressed by almost every tumor cell [ 24 ]. In support of this latter proposition, Slootweg[ 8 ] analyzed 33 mixed odontogenic tumors and found that the mean age of the patients with ameloblastic fibroodontoma was lower than that of the patients with AF. The flap was repositioned in the same position and suturing was done with vicryl 3.


Aggressive atypical ameloblastic fibrodentinoma: Report of a case

A microscopic examination revealed a small island and cords of odontogenic epithelium in a loose and primitive-appearing connective tissue that resembled dental papilla.

Author information Copyright and License information Disclaimer. Aggressive atypical ameloblastic fibrodentinoma: Peripheral extraosseous, soft tissue AF or AFO arising in gingival tissue is even rarer ameloblasitc their intraosseous counterparts [ 4 — 6 ]. Therefore, a radical resection dentinoa by resection was the treatment of choice. Abundant small blood vessels surrounded the odontogenic epithelium Figure 2.

The substance of the radiolucent area showed few flecks of radioopacity. How to cite this URL: It is usually slow developing and is usually seen in young persons with a mean age between 8 and 12 years [ 13 ]. Compared to their intraosseous counterparts, peripheral tumors are more located in maxillary arch anterior to first molars.

Studies have reported that CD44 is highly expressed in ameloblastomas [ 13 ]. Considering the clinical and radiological picture the possible differential diagnosis was calcifying epithelial odontogenic tumour CEOTadenomatoid odontogenic tumour AOT and ameloblastic fibro-odontoma.

Indexed in Web of Science. Second, there are several indications that amelogenin protein, highly expressed in the odontogenic epithelium of this lesion, is actually a proangiogenic molecule [ 23 ].

OPG showed unerupted tooth bud of upper right second molar and was being prevented from eruption by the odontome. Some of the stromal cells, leukocytes, and endothelial cells were also positive for CD44 staining. Amoxicillin and acetaminophen were prescribed for the patient. A pre-operative differential diagnosis of calcifying epithelial odontogenic tumor, mixed odontogenic tumor, calcifying odontogenic cyst and fibrosseous lesion was given.